June 2023

theCareer girlSupport online veterinary continue educationnewsGuest bloggerChristopher lee,Pet owners, DVM, MPH, DACVPM discussed in vaccines may be some hesitation.Now that the vaccine is listed as one of top ten public health achievements in the 10th century, why people fear of vaccine has so much as a veterinary professionals, what can we do?

Together with Dr Christopher Lee provide dog vaccine technology advantage

ByChristopher lee,DACVPM, DVM, master of public health

"Hey, doctor, why my chihuahua and my great Dane are the same dose of vaccine?=

"Well -=

"When I flu shot, it's only half an ml.Why does my dog get so many?Come on the doctor, you can't just give little one half?=

When we as a veterinary professionals to explore these pet owners problem behind the "why", we often find that fear of vaccine.Vaccine among the ten accomplishments of public health in the 20th century, but there are still many people hesitant to use.

The dog

Photo byHere no longer,sincePixabay

Elimination reaction as the vaccine can produce lasting memory, in some cases can last for decades or life, so everyone has a line - vaccinated before the time and the time after vaccination.Therefore, has accumulated a series of unlikely and may concern.

Unlikely association and subject to change with the passage of time, and often reflects the current culture.While inhibiting the smallpox virus caused a large number of death and deformity, campaign against vaccine or birth after vaccination, or may be the "foot".Use vaccinia to prevent the two major problems of deadly smallpox is "vaccinia scabies" and "cow mania".Cowpox scab is vaccinated individuals grow hoof and horn theory of risk, and cattle mania is may produce half-human children.

When considering known vaccine caused the disease, there are few events will stay in our minds, such as Cutter events of 1955.In the second day of the 18000 children vaccine trials prove successful, of the Salk polio vaccine licensed.Two weeks, five companies distribute nearly five million doses of vaccine.By design, these vaccines are inactivated or killing, therefore, should be no virulence to turn back.

Live polio virus pollutes the carter laboratory products.In less than two weeks, vaccination of polio infection report.By the end of the event, more than 200000 immunization workers infected with contaminated live polio vaccine.About half of the victims are children and the resulting complications including death, paralysis, and muscle weakness.In canine veterinary channels, distemper and the reversal of the rabies virus force, older leptospirosis vaccine response rate and the lack of expected curative effect still is our concern about vaccines.

To realize the importance of supervision, the United States can be considered at the forefront of to protect the public.From the USDA and AVMA origin, in the 1860 s to the early 1900 s, the FDA and the relevant laws, the standard of drugs and vaccines to improve.Specific to the veterinary drug, the FDA's veterinary centre (CVM) was founded in 1984, the United States department of agriculture (CVB) of the veterinary biological products center was established in 1996.

When pet owners trying to judge for yourself safety risk minimization options, they will think of the number soon.After all, human vaccine really owing to the different dose.Early vaccine, for example, early polio vaccine and Cutter distribution of vaccine, the volume is usually 1 ml.Today, most people 0.5 ml of inactivated influenza vaccine, but some people 65 and older may vaccinate larger doses of 0.7 ml.Many people are familiar with 0.25 mL COVID - 19 strengthen vaccine.Keep the volume of other vaccines in 1 mL.

Despite this scope, the dose of each age still is very strict.For example, a child 11 months and 29 days age of 18, regardless of weight or height, will accept 0.5 ml of hepatitis a.When he grew up in a few days, forced dose will be doubled.

The CDC contain immune practice advisory committee (ACIP) vaccine recommendations and guidelines.Their statement on reducing doses of vaccine is clear: "any use of below standard doses of the vaccine should not count."

In veterinary medicine, according to the virus - serum - toxin method (VSTA), the United States department of agriculture and veterinary biological products center (CVB) to ensure that the animals in the United States provide clean, safe, effective and efficient veterinary biological products.This includes determine the minimum for the each vaccine antigens or pathogen immune dose of the study.

AAHA vaccine XNUMX 2023 guide to solve the problem to reduce the amount of small dogs vaccine: "manufacturers recommend usually represent the minimum amount of immune dose;Therefore, we should always give the amount of vaccine doses.Any reduce the volume of a vaccine may cause immune response below protective.In addition, there is no evidence to suggest that reduce the dose of the vaccine can prevent adverse events/volume."

Aiming at minimum level of effectiveness helps to solve the problem of "my dog is too small, but not necessarily can answer" it is still too much "problem.Federal regulations article 9 (CFR) § 113.40 dog safety testing, before release any vaccine series: "should be in accordance with the recommended method on the label to each of two healthy dog dog 10 dose, and should observe the dogs every 14 days."

By combining AAHA small varieties problem and 9 CFR test, we can better understand the goalposts.If due to the pet of a swing in the dosing process lost some undefined number of vaccine, and so can provide another full dose represents the clinical safety, it is released by the vaccine manufacturers each batch of 10 times limited definition of security research institute.Therefore, regardless of size, every dog should be at least accept full dose to appropriate to prevent disease.

As people use and veterinary vaccines in terms of safety and effectiveness of continuous innovation, new options appear constantly.In the past ten years, many animal innovation, could make it challenging to choose a few examples.

An example include called SEQUIVITY ® RNA particle technology, the technology has been used to create customized prescriptions for specific influenza a virus strains pig vaccine.Can in a short span of XNUMX to XNUMX weeks for producers to develop specific pig vaccine.

In terms of companion animals,Merck animal health care companyNobivac EDGE ® series for the first time in the form of a half volume production of canine distemper, type 2 adenovirus, tiny and parainfluenza virus.The half volume series includes a four serotype of leptospirosis vaccine, the vaccine proved how can support to prevent data loss and death.Finally, all of these important antigen in 0.5 mL EDGE ® DAPPv + L4 options available.Due to pet owners have been using the method of less is more, could reasonably expect to get maximum protection at the same time, so the Nobivac EDGE ® series vaccine is a clear choice in vaccine innovation summit.

The resources:
1. Carapetis JR.Cutter events: the first polio vaccine led to increasingly serious crisis of the vaccine.The British medical journal.On 25, 332, in 2006;7543 (733) : 1410842.PMCID: PMCXNUMX.
2. The centers for disease control and prevention.(1999).Top ten public health achievements -- the United States, 1900-1999.The centers for disease control and prevention.https://www.cdc.gov/mmwr/preview/mmwrhtml/00056796.htm#:~:text=Ten%20Great%20Public%20Health%20Achievements%20 - % 20 20 states united % % 2 c, babies 20% % 20% % 208% % 20 planning has just 20 20 more % 20 items
3. The commissioner, o. of. (nd). Frances o. kelsey.The us food and drug administration.Since 18 years on XNUMX 2023 retrievalhttps://www.fda.gov/about-fda/fda-history-exhibits/frances-oldham-kelsey-medical-reviewer-famous-averting-public-health-tragedy
4. MDPD AMDPD director, director and director of the MDPD (18, 2023, 23 month).Vaccines can help everyone to live a better life.The international financial industry association.On XNUMX XNUMX retrieval since 2023https://ifpma.org/insights/vaccines-can-help-make-a-better-life-possible-for-everyone/
5. Fitzpatrick m. Britain's vaccination campaign, 1853-1907.JR, Soc medicine.98, 2005;8 (384) : 5-1181850.PMCID: PMCXNUMX.
6. McHugh, j. (2021, October 18).The world's first campaign against vaccine spread half-and-half cattle baby fears.The Washington post.On XNUMX XNUMX retrieval since 2023https://www.washingtonpost.com/history/2021/11/14/smallpox-anti-vaccine-england-jenner/

By the VETgirl online veterinary continue education blogMerck animal healthThe Nobivac ® vaccine manufacturers.Our dog is part of our family.We want to make sure that they stay healthy.Nobivac EDGE ® vaccine includes unique and effective 0.5 ml solution, with half of the volume to provide comprehensive protection.Very suitable for small dogs, but can also be used for large dogs.Will comfort into practiceNobby wack® vaccine.

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